Pa amb xocolata (Alisis) (Catalan Edition)


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Hervagius, This edition of Grynaeus is especially noteworthy as it contains the large woodcut world-map, "Typus Cosmographicus Universalis," and the additional letter of Maximilian of Transylvania, secretary of Charles V. This occupies pages to The famous World-map contains pictorial scenes illustrative of various parts of the world. On the left corner at the top a man is shooting an elephant with an arrow; in the lower corner is a cannibal scene, illustrative of America.

To the right is a portrait of Varthema, the famous Eastern traveller. The continent of America is not laid down, but Cuba is elongated and separated by a narrow strait from South America. In our copy, the map type A is found in excellent and quite untouched condition. It is printed on two sheets, each folded separately. On the Western half we find the New World represented on the north as a long strip of land, bearing the inscription Terra de Cuba. The isthmus is cut asunder. On the old continent the name Asia printed in large type. This map, within a richly ornamental border, and the two woodcuts in the text, are by Hans Holbein.

Nordenskjold, Facsimile Atlas, Plate 42, does not reproduce this scarce map, being apparently unable to find a copy to photograph, but had to content himself with a copy of variant B, which differs only in slight particulars. Among the other contents of this famous work, are: The three voyages of Columbus, Voyages of Petrus Alonzo.

Voyage of Vincent Pinzon to Brazil in Epitome of the voyages of Vespucci by Alberi Vespucci. The first, second, and fourth voyages of Amerigo Vespucci. Accounts of the travels of Varthema and Marco Polo. Peter Martyr's account of the newly discovered Islands. Not to De Viaoriisha' bitds in India,.

LconeimXo Pont. Maxit mum. See Ittem No. ROME, 15I4. Title printed in red and black containing fine large woodcut showing two angels supporting the Arms of Genoa, with inscription. Fine large woodcut on the reverse of title showing St. George killing the Dragon, and fine woodcut initial letters. Bound by David in full blue levant morocco gilt, inside dentelles, g. Genoa, Antonio Bellono, i8th March, I This work contains on folio an interesting account of Columbus, and a mention of the bequest supposed to have been made by the Admiral " all ufficio di.

Georgio la decima parte," of all he owed, for the erection of an hospital, we believe. The passage is sometimes cited to impart an air of authenticity to the codicil, made according to military usage, and written on a blank leaf of a breviary, said to have been presented to Columbus by Alexander VI, and found afterwards in the Corsini Library at Rome, or picked up in a book-stall, and purchased for a few cents.

Sphera Volgare novamente tradotta con molte notande additione di geometria, cosmographia, arte navicatoria, et stereometria, proportioni, et quantita delli elementi, distanze, grandeze, et movimenti di tutti li corpi celesti, cose certamente rare et maravigliose. With fine woodcut borders. With geographical, astrological and heraldic woodcuts. Venice, Bartholomeo Zanetti, The cosmographical woodcuts include two globes depicting America.

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Conduit Street, London, W. Rerum toto orbe memorabilium thesaurus. Pomponii Melae de situ orbis. With numerous large woodcut maps in the text, and two double-paged maps, on one of which America " Terra Incognita " appears. Crimson levant morocco, gilt lines on sides, gilt back, inside dentelles, g. Basel, Michel Isengrin and Heinrich Petri, L2I Not in Harrisse. No copy in the Church Catalogue.

The present copy is a tall one, in a superb condition. Obra muy util y provechosa para todo genero de mercaderes: como de Senores de Navios y Pilotos y Marineros y todos los que navegan. De mas de tener clara luz para en todos los negocios de la mar o concernientes a ella tiene agora nuevemente las ordinaciones de los derechos del general y del Peso del Senor Rey, etc. Traduzido de lengua Catalana en Castellana. Title printed in red and black, surmounted by a fine woodcut of sailors and ships and surrounded by a woodcut border, double columns.

Valencia, Francisco Diaz Romans, L75 A. Obra compuesta por Gothic Letter, 48 lines to a full page. Full blue morocco binding, treble gilt fillet border,. Alcala de Henares, Juan de Brocar, Very fine copy. This work, which records the memorable events in Spanish history up to the time of Charles V, includes a long account of the reign of Ferdinand and Isabella, mentioning the American possessions, and the curious statement that "Pedro Colon" was sent out with a fleet to explore the Atlantic.

As Harrisse comments, "the great decay of letters in Spain under John II, Henry IV and even of Ferdinand and Isabella, was followed by a revival, due chiefly to the example of Italy at that time, and the influence of a few Italian scholars who had made Spain the land of their adoption, among whom the author of the work before us may be said to have exercised a greater influence than any other. Lucius or Lucas Marineo, called Siculus, owing to his Sicilian origin, was born about the year He was afterwards appointed to the offices of Royal Chaplain and historiographer, and is supposed to have died shortly after the year De Orbis situ libri tres.

With large folding double-page map of the World. Bound by Petit in full levant morocco, gilt lines on sides, fully gilt back, inside dentelles, g. Paris, Jean Roigny, De la Sfera del Mondo. Libri Quattro in Lingua Toscana. Dele Stelle Fisse. Libro uno. With various mathematical diagrams in the text, and 48 full-page charts of the heavens, shewing the various constellations.

The two works in one volume. Venice, al segno del Pozzo, Portuguese Manuscript with two coloured drawings of the compass. Very charming contemporary French binding by Eve in dark olive morocco, the entire surface covered in delicate gilt tooling, in a design of scrolled and dotted fleurons joined by curved olive branches, open oval medallions on sides, trails of gilt olive leaves tooled on back, g.

Lisbon , circa I Thevet, The manuscript does not describe any particular voyage, but appears to summarise the observations and experiences of a skilled navigator who had made the voyages many times and was able to give valuable advice as to the most suitable seasons for travelling, and the safest geographical course.

There is a table, giving the daily declination of the sun for a period of four years; and two coloured drawings showing the points and degrees of the compass. Andre Thevet, who owned this book, was a French traveller, who was born at Angouleme in , and died in Paris in As a Franciscan Friar, he was a profound scholar and reader; and, wishing to augment his knowledge by travel, he obtained permission to visit Italy, where he met Cardinal de Lorraine, who gave him the necessary money for a voyage to the East.

He embarked at Venice in , and on reaching Constantinople, made the acquaintance of Peter Gillius, with whom he explored Asia Minor, and whom he assisted on his archeological expeditions. He proceeded to Rhodes, Athens, and Palestine, returning to France in with a relation of his fascinating travels, which was very well received. The following year, he embarked with Villegagnon for Rio de Janeiro, but was deprived of the pleasure of seeing the country on arrival, owing to illhealth, which compelled him to return to his native country; but, nevertheless, did not prevent him from making a description of Brazil.

See Item NVo. Repertorio de tiempos nuevamente corregido por el famoso doctor Gothic Letter; title within woodcut border; numerous woodcuts of figures and astrological signs; full-page figure, illustrating the various parts of the body ruled by the planets and signs of the zodiac. Small 8vo. Crimson morocco, gilt fillet border, gilt panel back, inside dentelles, g. Granada, A curious and rare little book, containing chapters on the signs of the zodiac and its influence on human life; astronomical tables and calculations for hours, days, phases of the moon, sunrise and sunset, and all the known methods of arranging the calendar: a work which was invaluable to a sixteenth-century navigator.

Brevissima totius habitabilis Terrae Descriptio. Paris, Christian Wechel, The final chapter of this work deals with the regions not known to Ptolemy, and occupies the last three pages. Domingo, in a passage which reads in translation: "Farther towards the west, lies a country called America, the length of which is about eighty degrees.

There are two islands, Spagnolla and Isabella. Those countries have been visited along the coasts by the Spaniards, Colombo of Genoa and Americo Vesputio being the leaders of the navigation. There are people who believe that in the times of Caesar Augustus that country was known, and that Virgil in the VIth book, verses of the Aeneid, wrote the following lines concerning the same: 'Their land lies without the signs of the Zodiac , beyond the Sun's annual course, where Atlas, supporting Heaven on his shoulders, turns the axle studded with flaming stars.

Therefore he himself explains 'beyond' as meaning 'almost beyond. De situ habitabilis orbis. A large and interesting woodcut on title containing two spheres issuing from an open eye, and a spherical map having " America " on it. Morocco gilt, g. Simon Lemnius' address at the beginning of the volume contains some fifteen lines on Amerigo Vespucci, Columbus, and the discovery of America. With numerous astronomical and geometrical diagrams throughout the text. One of Giunta's woodcut devices on the title, and another mark occupies the verso of the last leaf of text.

Dark olive green morocco, gilt sides and back, g. Additions This very rare volume contains five passages concerning America, Columbus and Vespucci. The present copy is in a truly magnificent state of preservation, with ample margins. He was the greatest geometrician of his times. Libellus de Sphaera. With 2 revolving, and other diagrams. Libellus de Anni Ratione, seu ut vocatur vulgo, Computus Ecclesiasticus.

Bound in I vol. Half cloth binding. Wittemberg, Peter Seitz, ; and N. The fame of John Holywood, or Halifax, of Oxford, rests entirely upon his "Sphera," a little work in four chapters, which treat respectively of the. De orbis terrae concordia libri quatuor. Bound by David in crimson levant morocco, gilt lines on sides, gilt back, g. Sabin, Harrisse, In the first book, Postel exposes the dogmas of the Christian religion; in the second, after an investigation into the life of Mahomet, he examines the Koran and refutes it; in the third he develops the notions of natural law and the principles of right accepted by all religions; finally in the fourth book he indicates the means to be employed to lead the pagans, Turks, and Jews to the Christian religion.

This last book contains a passage, beginning of p. The present copy is in a remarkably fine state of preservation. Fides, Religio, moresqu Aethiopum. Deploratio Lappianae gentis. Lappiae descriptio. Bellum Cambaicum. Pro Hispania adversus Munsterum defensio. Louvain, December, I Arte de Navegar, en que se contienen todas las Reglas, Declaraciones, Secretos, y Avisos, que a la buena navegacion son necessaries, y se deven sabar, Dirigida al serenissimo y muy esclarescido seinor, Don Phelipe principe de Espania, y de las dos Sicilias. Title in large Gothic Letter, red and black, with woodcut Coat-of-Arms, within narrow woodcut border.

Gothic Letter, 41 lines to a page, double columns. Woodcut maps and numerous astronomical charts in text. Full crimson morocco; gilt fillet border; gilt panelled back; richly gilt doublures in crushed blue morocco, g. Of special interest is the full-page woodcut map of the world in which Florida, Mexico, the Amazon, Peru and the city of Los Reyes Lima are specifically named. The author, who was with Cortes, may be said to have been the founder of the literature of seamanship. He was entrusted by the King with the examination of pilots and sailing-masters for the West Indies, taught navigation, and was held in high esteem as a cosmographer.

This book was most popular with the successors of Columbus and was translated into several languages. The map may be taken as embodying the result of Spanish discovery in , as reported to Medina by the pilots, with whom his official position as examiner brought him into constant intercourse. It shows the mouth of the Mississippi, and the lands around the river and Gulf of the Saint Lawrence. Newfoundland had not yet been discovered to be an island.

The river Saguenay is here indicated, a remarkable feature in so early a map. Agora nuevamente traduzido de Latin en lengua Castellana por el Bachiller H. With numerous woodcut diagrams. Title within woodcut border; Gothic Letter. With additional woodcut frontispiece. Seville, Juan de Leon, I A valuable Spanish translation of Sacrobusto's famous Sphere with interesting notes and additions by a celebrated cartographer of the New World.

Jeronimo de Chaves, mathematician, cosmographer, and poet, was born in Seville in , and died in He was Professor of cosmography, when that chair was established at the Casa de la Contratacion; and amongst his publications was a map of America. He bequeathed his maps, instruments, and original cosmographical works to the Monastery of La Cartuja at Seville, inserting a clause which forbade their removal under any circumstances.

The Library was destroyed, however, and only some of Chaves' geographical works could be rescued. The Espasa Enciclopedis comments upon the interest of this particular clause, " both as regards the classification of the works that were found, and with reference to the earliest cartography of the New World. This is of course the work of Chaves, whose large map of the New World is said to have never yet been printed. With numerous diagrams, one revolving, relating to Astronomical, Geographical, Geometrical, and Trigonometrical problems.

Levant morocco, inside dentelles, g. Paris, Jehan BarbS, With the series of I3 woodcut maps, the folding map of the World shewing America. Small vignette on title. Green morocco eighteenth century , g. Zurich , Froschouer, I The Heber-Herschel V. Jones copy. The little Atlas containing the 13 maps is found at the end of the volume.

Humboldt seemed to think that it formed a separate work, sometimes bound up with the Cosmographia, yet the words " cum tabellis Geographicis " imply that the maps are part of the original work. The three preliminary pages of the Atlas contain three further diagrams, one of which is a small map of the world also shewing America. The work itself is in the form of a poem. This is a very fascinating little book written by a very interesting person. John Honter, claimed both by Hungarians and Rumanians as their compatriot, was born in Cronstadt in Transylvania, educated at Basle and Cracow University, and became a Reformist, took refuge in Cracow, where he was appointed professor of Geography in the University, and afterwards returned to Transylvania.

His biographers call him the first important reformer who introduced the Reformation into Transylvania. He died there in The book was a popular one and passed through many editions. Some of these are described by Harrisse, Sabin, Estreicher, and most fully by the Hungarian bibliographer Szabo. Paraphrase de l'Astrolabe, contenant: Les Principes de Geometrie. La Sphere. L'Astrolabe, ou, declaration des choses celestes. Le Miroir du Monde, ou exposition des parties de la Terre. With various Geographical and Astronomical diagrams, including 2 volvels revolving figures.

Magnificent copy in full levant morocco, gilt, g. Lyons, Jean de Tournes, On page 34 is a small world-map, including America, and on page occurs the following remarkable statement:-"Telle est la description des parties du monde, selon le tres excellent Ptolomee, et les autres anciens Geographes: depuis I. L'Amerique laquelle est appellee l'Ameque te descriray succinctement, suyvant la metode de Ptolome'e, n' ayant egard it tous ceulx qui ont navige, et pour le jourd'huy navigent Ai intention seulement de traffiquer, ou gaigner, et d'icelle- parlent obscurement, tellement qu'il fault presque deviner ce que par leurs songes veulent dire.

Towards the Antarctic pole the people are giants an early reference to the Patagonians , and in the far west they are cannibals. With 4 diagrams in the text. M is Chapter treats of navigation to the New World. John Holywood of Oxford. With numerous geographical and astronomical diagrams. Fine copy in full morocco, g. Paris, Jehan Loys, Isolario Di Benedetto Bordone. Nel qual si ragiona di tutte l'Isole del mondo con li lor nomi antichi et moderni, histoire, tauole, et modi del loro viuere et in qual parte del mare stanno et in qual parallelo et clima giaciono.

Ricoreto et di Nuouo ristampato. Con la gionta del Monte del Oro novamente ritrouato. With fine large double-page map of the world, showing the New World and numerous other maps. Bound by Petit in full red morocco, gilt lines, gilt panel back, g. Venice, Federico Toresano, I Harrisse, No. With the Atlas of 13 woodcut maps, and 3 diagrams, at the end, two of which contain America. Vignette on title. Contemporary calf binding, with blind tooling on sides.

Zurich , Froschouer, Libro dela Cosmographia, el qual trata la descripcion del Mundo, y sus partes, por muy claro y lindo artificio, augmentado por el doctissimo varon Gemma Frisio, doctor en Medecina, y Mathematico excellentissimo: con otros dos libros del dicho Gemma, de la materia mesma.

Agora nuevamente traduzidos en Romance Castellano. Woodcut of a Globe on the title; 5 woodcut revolving diagrams;. Antzwerp, Gregorius Bontius, The accounts of America occupies folio The folding map of the world shows all of America, the Southern part bearing the name "America," and Northern the word "Baccalearum. De Navigatione Libri Tres. Decorative border to title, and diagrams in the text. Calf, gilt.

Paris, Reginald and Claude Calder, They now belong to Great Britain and are known as the most isolated islands in the world. I55I A. Historia do descobrimento e conquista da India pelos Portugueses. Title within woodcut border, printed in Roman letters. Bound by Rousselle in blue full levant morocco, 'gilt lines and fleurons on sides, full gilt back, doublures of crimson levant morocco elaborately tooled to a geometrical pattern, watered silk fly-leaves, g. This is the only known copy of this very rare work, which has been translated into many languages.

Copia de unas cartas embiadas del Brasil, por el padre Nobrega de la Companhia de Jesus: y otros padres.. Tresladadas de Portugues en Castellan. Woodcut of a galleon on title. Lisbon, circa I Medina, This scarce and valuable pamphlet is divided into six chapters, comprising: Information relating to various parts of Brazil, by Father Nobrega.

Letter from Father Nobrega, Pernambuco, Vincente, Breve Compendio de la Sphera y de la arte de navegar, con nuevos instrumentos y reglas, exemplificado con muy subtiles demonstraciones. With various revolving and other geographical and astronomical diagrams, including a full-page map of America. Seville, Anton Alvarez, I A work of great rarity. The full page map of America occurs on folio The English Edition was translated by Richard Eden.

With 54 fine woodcut double-page maps. Basel, Henrich Petrus, I a little worming. Phillips' List of Atlases, No. This is the fourth edition of Miinster's Ptolemy, with his long Geographical Appendix at the end, and containing an additional treatise " on the use of maps " at the beginning.

The indices, by Conrad Lycosthenes i. There are two remarkable World Maps: " Typus Universalis," including the whole of America, bearing the names "Terra Florida," in the north, and "America vel Brasilii ins ula " in the south, and also bearing the names " Corterati," Hispaniola, Cuba, and Fretum Magellianum. This map is somewhat altered from that in the Ptolemy.

The second world map, "" Typus Orbi8 Ptol. Descriptus," is the old map of the world before the inclusion of America. Of the other maps, two relate to America, namely, "Sepfentrionales Regiones," or a map of Scandinavia and part of Greenland; also " Novae Insulae," this is an important map and shews the whole of the American Continent. Some of the West Indian Islands are named, and the flag of Spain is shown flying there. Yucatan is given as an island adjoining Cuba.

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The descriptive text for the maps is given on their reverse, generally within fine woodcut borders, which have been attributed to Hans Holbein. Miinster was the first to give separate maps for the four parts of the world, and he gives his sources for the " modern " maps.

Brevissima relacion de la destruycion de las Indias. Lo que se sigue es un Pedaqo de una carta y relacion que escrivo cierto hombre, etc. Entre los remedios que don fray Bartolome de las Casas.. Aqui se contiene treynta proposiciones muy juridicas. Aqui se contiene vna disputa Un tratado sobre la materia de los Indios que se han hecho en ellas esclavos. Aqui se cotiene unos avisos y reglas para los confessores que oyeren confessiones de los Espafioles que son o han sido en cargo a los Indios de las Indias del mar Oceano.

Principia quedam ex quibus procedendum est in disputationibus ad manifestandam et defendendam Justiciam Indorum. Tratado comprobatorio del Imperio soberano y principado universal que los Reyes de Castilla y Leon tienen sobre las Indias. Seville, Trugillo, Sabin, Nos. Excessively rare. A Complete Set of these original treatises, containing the nine parts as issued. All First Editions. With title-pages nearly all printed in red and black with woodcut borders. Dibdin remarks: "This History is a prodigiously great gun in the bibliographical battery of collectors; especially if the Bartolome de Las Casas, the Apostle to the Indians of the Sixteenth Century, was born in Seville in of aristocratic lineage, and died at Madrid in In he went with Nicolas de Ovando to Hispaniola, where he settled, and in was ordained a priest.

In he went as curate to a village in Cuba. He soon began to preach against the atrocious wrongs committed by the Spaniards against the natives, under a system of slavery the most cruel and destructive the world has ever known. This drew upon him the animosity of his countrymen. Unable, by any means in his power, to check this cruelty, in he returned to Spain to make a personal appeal to his sovereign.

Ferdinand's death, which happened soon after his arrival in Seville, put an end to his hopes in. BASEL, He returned to Hispaniola Nov. At last wearied with his efforts and lack of success, he retired to a Dominican convent in San Domingo, in He there spent eight years in retirement, occupied in study and writing. His work was not at first allowed to be printed, but was submitted to the Emperor and his ministers. Twelve years later the work was published with a dedication to Philip, the heir to the throne. Though the number of victims was contested, it should be remarked that the acts of cruelty which he described were never called in question.

One of the most gruesome books ever written. These four leaves which are appended to the Brevissima Relacion are usually mentioned as a separate tract, though it is really a part of that work. It contains the narrative of a Spanish traveller who witnessed some of the cruelties practised upon the natives by the Spaniards. This tract gives the eighth of the proposed remedies, and assigns twenty reasons to prove that the Indians should not be given to the Spaniards in any form of slavery.

The Bishop, during his absence in Mexico attending a council, had written twelve rules to the confessors whom he had appointed in his diocese to govern them in giving absolution. Complaint having been made to the Council of the Indies of the rigour of these rules, the thirty propositions were written to sustain them. This tract contains a strong enunciation of Las Casas' convictions, which grew out of his controversy with Sepulveda. It contains, first, a summary, by Domingo de Soto, of the differences between the two disputants; second, the arguments of Sepulveda; and third, the twelve replies of Las Casas to the same.

This tract contains judicial authorities and reasons why the natives should be restored to freedom. This tract was written in America in or , for the direction of Confessors, during Las Casas' attendance at the council held in the City of Mexico, in , and may first have been printed in that city.


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By these rules the Confessors of his Bishopric were instructed to deny the offices of the Church to all such persons as held repartimientos, or who did not restore the avails of unrequited labour to the Indians. This tract gives the principles on which Las Casas conducts his defence of the rights of the natives, and was evidently written to familiarize the Clergy with the principles upon which he based his whole theory of the rights of the Indians to personal liberty and rights of property.

The purpose of this tract is to prove the sovereign Empire and universal dominion by which the Kings of Castille and Leon held the West Indies. Primera y Segunda Parte de la Historia General de las Indias con todo el descubrimiento, y cosas notables que han acaescido dende que se ganaron hasta el ano de I55I. Con la conquista de Mexico, y de la nueva Espafia. Title, in red and black, with the Arms of Spain nearly filling the page, on reverse a list of the historians of the Indies; large woodcut of a Bison on folio II, Vol.

The Two Parts in one volume. Medina del Campo, Guillermo de Millis, The Second Part gives an account of the Conquest of Mexico, and is that portion of the work by which its author is best known. This is a great historical work, indispensable to the student of Spanish affairs in America after the Conquest.

Gomara prefixes a curious address to intending translators, warning them to be accurate and to measure the full significance of the pregnant Spanish phrases, also to pay special attention to proper names. He further declares that he is writing the book in Latin, so that the translators may take no trouble in that language. His Latin version never appeared. A fine copy, with only two slight defects, viz. Some facsimiling to the first two leaves. Gomara was one of the earliest and at the same time one of the ablest of the Spanish historians of the New World. In he was the Chaplain and Secretary to Cortes,his connexion with whom gives value to his work, especially as he had access to many documents which have since disappeared.

Parte Primera de la chronica del Peru, que tracta la demarcacion de sus provincias: la descripcion dellas. Las fundaciones de las nuevas cindades. Los ritos y costumbres de los Indios y otras cosas estrainas dignas de ser sabidas. Woodcut Coat-of-Arms on title-page; title printed in red and black in Gothic and Roman, within woodcut border; woodcuts depicting scenes from the life of the Spanish settlers in Peru, repeated in the text; Gothic letter, forty lines to a full page, double columns.

Marginal repair to title-page. Seville, Martin de Montesdoca, I It is, in fact, the only book which exhibits the 'physical aspect of the country as it existed under the elaborate culture of the Incas '. He started the work at Popayan in and finished it in Lima in ; the full chronicle consisted of four volumes, of which only the first was published, and deals with the geography, history and ethnology of Peru.

According to Leclerc, the three remaining books dealt respectively with: the history of the Incas; the Spanish conquest; and the history of the civil wars. Paris , Michel de Vascosan, I This was the first translation printed of Castanheda's original Portuguese work, No. It relates principally to the East Indies, but contains some particulars of the Portuguese conquests in the New World, and is included in Dr.

Robertson's " Catalogue of Authorities. La lamentable destruycion y espantoso fuego que se encendio en la nao de Lope Hortiz que aya gloria que salio de Sanlucar por capitana en el armada que fue para Indias; de la qual fue general Bartolome Carrefio, vezino de Triana. La qual salio de la barra a quatro dias de Noviembre del aino de mil y quinientos y cincuenta y dos anos.

Hechas por Hernando de Verduras. In verse. Black Letter, woodcut of ship on title, with fine woodcut border, double columns. Half morocco. Madrid, I Not in Salva. L'Art de Naviguer de M. Pierre de Medine, Espagnol. Contenant les reigles, secrets, et enseignements necessaires a la bonne navigation. Title within fine woodcut border and numerous diagrams, and other woodcuts. Lyon, Guillaume Rouville, I Very fine woodcuts of ships and diagrams, also fine woodcut initial letters.

On page 1 there is an interesting small world map surrounded by winds, in which North and South America are shewn. Las Migas , the charismatic female new-Flamenco band, will be giving six concerts in Central Europe in the next few months. Els Berros de la Cort is a folk band specializing in the repertoire of medieval Catalan and Occitan troubadours, who have created their own unique universe of medieval mysticism. The result, however, is far from being a museum piece, and their concerts are both powerful and theatrical.

On 12th July, Berlin will host the Spanish Rock Invasion, a festival featuring bands from Spain, including Los Mambo Jambo , an instrumental outfit from Barcelona who pay tribute to rock 'n' roll, rhythm'n'blues and swing of a vintage nature. Los Mambo Jambo includes renowned musicians such as saxophonist Dani Nel.

In the final section of our podcast, we have three new and highly recommendable new albums. A genuine treasure chest of unorthodox music. This zone exerts a tight control over many crucial tasks such as growth promotion and the recreation of essential biochemical and physical cues for neural cell differentiation. The cytoskeleton is stained red, the nuclei blue and proliferative nuclei green. Another molecule, an integrin, appears in blue. A later prototype also incorporates biomedical sensors to analyze respiration data.

The normal function of dardarin or how mutations lead to the disease, however, have long been elusive. This new discovery — which has been made possible by the use of induced pluripotent stem cells from patients, already proving that it is applicable to humans — may help uncover specific strategies for dealing with or even preventing the neurodegenerative motor disorder.

Stepping up our understanding of cellular function Also in March, an IBEC researcher and his collaborators uncovered the crucial role of two molecules in enabling cells to communicate with their environment. Instead of using gears, however, cells employ molecules. In the paper published in Nature Neuroscience, the researchers revealed their discovery that dardarin is broken down by a cleaning-up process called autophagy, which enables the recycling of amino acids of degraded proteins and eliminates abnormal or damaged ones.

But dardarin uses a very specific type of autophagy and does it in a rather peculiar way, so that its mutations are also able to strike out at autophagy itself and undermine its efficiency. May Shedding new light on myelination and potential MS therapies Research done at IBEC and published in Cell Mol Life Sci in May revealed a hopeful new lead in the quest to understand neurodegenerative diseases such as multiple sclerosis. Oligodendrocyte precursor cells OPCs in the central nervous system differentiate into oligodendrocytes, which produce myelin to protect and insulate the long nerve cells in the brain and spinal cord.

MS is known to be a demyelinating disease: that is, a disease that results from the progressive breakdown of myelin in the central nervous system. When this happens, the central nervous system reacts by using proliferating adult OPCs to remyelinate. However, several factors affect the production and differentiation of these OPCs, one of them being the enzyme PDE7, which compromises their proliferation, differentation and survival. The scientists looked at cells in the neural crest, a very mobile embryonic structure in vertebrates that gives rise to most of the peripheral nervous system and to other cell types in the cardiovascular system, pigment cells in the skin, and some bones, cartilage, and connective tissue in the head.

Understanding more about how and why cells move the way they do can lead to valuable insights into how and why cancers occur and spread. Pioneering breakthrough in drugs controlled by light A cooperation between chemists, biotechnologists and physicists headed by Pau Gorostiza from IBEC and Ernest Giralt from the Institute for Research in Biomedicine IRB led to a breakthrough that will favor the development of light-regulated therapeutic molecules. The photo-switchable molecules to control protein-protein interactions in a remote and non-invasive manner will serve as a prototype to develop photo-switchable drugs, whose effects would be limited to a given region and time, thus reducing the side effects on other regions.

The scientists synthesized two peptides which, on irradiation with light, change shape, thereby allowing or preventing an specific protein-protein interaction. The association of these two proteins is required for endocytosis, a process by which cells allow molecules to cross the cell membrane and enter. Laura Nevola, a postdoc in Dr. The team was been supported by Dr. The researchers highlight the immediate applicability of these molecules to study, for example, in vitro endocytosis in cancer cells — where this process is uncontrolled — which would allow selective inhibition of the proliferation of these cells.

Also, they would also allow the study of developmental biology — where cells require endocytosis to change shape and function, processes that are orchestrated with great spatial and temporal precision. In this context, photosensitive peptides will allow the manipulation of the complex development of a multicellular organism by means of light patterns.

The combination of drugs with external devices to control light may contribute to the development of personalized medicine in which treatments can be adapted to each patient, limiting the time given regions are treated, thus markedly reducing unwanted effects. Unexpected discovery about the ways cells move could boost understanding of complex diseases Researchers at IBEC and Harvard School of Public Health found that epithelial cells— the type that form a barrier between the inside and the outside of the body, such as skin cells—move in a group, propelled by forces both from within and from nearby cells to fill any spaces they encounter.

Their study, which appeared on the cover of Nature Materials in September, may provide scientists with crucial information about. Laura Nevola, IRB. Scientific Highlights disease mechanisms such as the spread of cancer or the constriction of airways caused by asthma. Using a technique called monolayer stress microscopy—which they invented themselves—they measured the forces affecting a single layer of moving epithelial cells. As they expected, the researchers found that when an obstacle was placed in the path of an advancing cell layer—in this case, a gel that provided no traction—the cells moved around it, tightly hugging the sides of the gel as they passed.

However, the researchers also found something surprising—that the cells, in addition to moving forward, continued to pull themselves collectively back toward the gel, as if yearning to fill the unfilled space. August Engineering biomaterials at the nanoscale IBEC researchers came up with a groundbreaking new approach to create a tough, biodegradable, bioactive and entirely new material, heralding a major milestone in the production of artificial matrices for tissue engineering.

In a letter published in Interface in August, the Biomaterials for Regenerative Therapies group describes a new, easy and cheap method for producing glass-coated fibrous scaffolds which not only faithfully mimic the extracellular matrix of bone, but also aim to direct stem cell fate through physical and chemical interactions. The team coated nanostructured, electrospun polymer fibres with bioactive glass, assembling hybrid nanofibres with a strong union between the fibre and the coating — effectively creating a new material, rather than simply a composite.

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Previous attempts, which usually involved ceramic or glass being dispersed into a polymer matrix, which improves resilience, have always resulted in a loss of bioactivity and the collapse of the architecture. They will provide the right chemical signals, topography, and mechanical properties to the cells to promote differentiation into a particular cell lineage, stimulating the formation of new tissue. Not only have some common infections or illnesses become. This means that some clinical procedures like organ transplants, chemotherapy or the care of premature infants could become too dangerous to carry out, as hospitals become hotbeds for highly resistant pathogens.

Other researchers at IBEC are also involved in the fight against antibiotic resistance. Scientists at IBEC and their colleagues at the Mechanobiology Institute of the National University of Singapore used microfabricated technology — miniature structures at micrometer scales — to look at how skin cells migrate to fix gaps or wounds. Migrating skin cells are then able to continue to march forward as a united and homogenous group to form a protective barrier over the wound.

This committee ensures practices and criteria are implemented in accordance with international standards of excellence in research. Josep A. Moreover, being located on the same campus, the relationship with both universities and the access to their facilities — library, scientific services, etc — is very fruitful. The research groups at the two universities which are officially associated with IBEC are listed on page Enric I. Jeffrey J.

Bibliotheca americana et philippina. [Vol. 1, no. 5]

Samuel I. Bernt E. Charles J. Structure and function of bacterial proteins that modulate virulence expression; bacterial plasmids and their role in transmission of multidrug resistance markers; application of nanotools of bacterial biotechnology 1. Structure and function of bacterial proteins that modulate virulence expression Protein—protein and protein—DNA interactions play key roles in the ability of virulent bacteria to adapt to the host environment and cause disease.

A group of proteins is currently the focus of our research: nucleoid-associated proteins NAPs that contribute to DNA architecture and modulate gene expression. We are interested in unravelling the role played by two of these proteins — Hha and H-NS — in the regulation of virulence and of plasmid transfer. Escherichia coli pathotypes such as enteroaggregative E. Owing to their key modulatory functions, these proteins are interesting targets to combat bacterial infections.

Bacterial plasmids and their role in transmission of multidrug resistance markers A main concern with bacterial infections is the selection of isolates that are resistant to several antimicrobial drugs. The transmission of the ability of bacterial cells of simultaneously resist several antimicrobial drugs is accomplished, in many instances, by plasmids.

These genetic elements can be transmitted from one cell to another, and modify the phenotype of the recipient cell. We have recently shown that multidrug resistance plasmids in Salmonella require specific plasmid proteins to be stably maintained in this microorganism. These proteins could be considered as targets to combat multidrug resistance.

Application of nanotools of bacterial biotechnology 3. Dielectrophoresis DEP. We have previously shown that dielectrophoresis can be a valuable tool for bacterial cell sorting and characterization. We are currently using different chip designs 2D and 3D carbon electrodes to: a study the effect of electric fields on bacterial cell physiology; b combine DEP with other molecular protocols for detection and identification of different types of cells.

Atomic force microscopy AFM. Conventional AFM approaches have been shown to be powerful techniques for characterizing both biomaterials and biomolecules. In a joint project with the Nanoscale Bioelectrical Characterization group page 76 , we intend to use electricalAFM to characterize the bacterial cell envelope. We also plan to use this approach to analyze the structural and physiological properties of bacterial living cells. Duarte, R. Increasing PCR sensitivity by removal of polymerase inhibitors in environmental samples by using dielectrophoresis.

Biosensors and Bioelectronics, 43 1 , Quartz tuning fork studies on the surface properties of Pseudomonas aeruginosa during early stages of biofilm formation. Colloids and Surfaces B: Biointerfaces, , Collaborations with other research centres Prof. Madrid, C. H-NS is a novel transcriptional modulator of the ribonucleotide reductase genes in escherichia coli.

Journal of Bacteriology, 18 , The Hha protein facilitates incorporation of horizontally acquired DNA in enteric bacteria. Microbiology, 3 , Queiroz, M. Role of plasmid- and chromosomally encoded Hha proteins in modulation of gene expression in E. New insights in the role of HtdA in the regulation of R27 conjugation. During , the group has developed several studies aimed at understanding some processes of development and neurodegeneration of the central nervous system CNS.

Role of PrPc in the nervous system We have demonstrated, in collaboration with other groups, the role of the cellular prion protein PrPC in neural stem cell proliferation and differentiation, in particular hippocampal neuronal progenitos and during the last year neuroblastoma cells using -omics techniques. We determined the PrPC -dependent gene expression signature in N2a cells and its implication in the most overrepresented functions: cell cycle, cell growth and proliferation, and maintenance of cell shape. PrPC over-expression enhances cell proliferation and cell cycle re-entrance after serum stimulation, while PrPC silencing slows down cell cycle progression.

These effects are due in part to the modulation of epidermal growth factor receptor EGFR by PrPC in the plasma membrane, where the two proteins interact in a multimeric complex. This data has been reviewed in Llorens et al. On these mouse lines, we investigated the influence of each protein on the evolution of both diseases. In our studies we used biochemical, Transmission Electron Microscopy and Atomic Force Microscopy experiments to demonstrate that the CD peptide is able to activate caspase-3 and disrupt the cell membrane, leading to neuronal death Vilches et al. Regenerative neuroscience Moreover, in collaboration with SSSA in Italy we reported a system based on modified olfactory ensheathing cells OECs carrying magnetic nanoparticles as a proof of concept experiment enabling specific studies aimed at exploring the potential of OECs in the treatment of spinal cord injuries.

Our studies have confirmed that magnetized OECs survive well without exhibiting stressassociated cellular responses, and that their migration can be modulated by magnetic fields. Example of fluorescence microscopy picture showing one example of cultured motorneurons red and glial cells green in microfluidic lab on a chip devices after 15 days in culture. Finally, group members have collaborated on the study that identificates Ack1 as a novel regulator of neurotrophin-mediated events in primary neurons and in PC12 cells La Torre et al.

These isoMIRs may contribute to the overall effect as quantitative and qualitative fine-tuners of gene expression Llorens et al. In addition, from our studies we propose that the use of global genomic miRNA cross-validation derived from high throughput technologies can be used to generate more reliable datasets inferring more robust networks of co-regulated predicted miRNA target genes Llorens et al. Furthermore, we also collaborate to determine that the endogenous phosphodyesterase 7 is involved in multiple sclerosis Bribian et al.

In particular the migration of pioneer neurons, Cajal-Retzius cells, is already being analyzed using these transgenic mice. Fluorescence microscopy picture showing one example of cultured hippocampal neurons extending their neuritis inside a microchannel in a microfluidic lab on a chip device after 15 days in culture. The axon of the neurons is labeled in green and the dendrites in red. Neurobiology of Aging, 34 12 , Elisabeth Engel page 90 , Prof. Josep Samitier page 70 , Prof. Xavier Trepat page 64 , Prof. Marc Tessier-Lavigne Genentech, Inc. A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching.

Cell Death and Disease, 4 4 , e Pantano, L. Microarray and deep sequencing crossplatform analysis of the mirRNome and isomiR variation in response to epidermal growth factor. BMC Genomics, 14 1 , Torres, J. PrPC regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells. Journal of Neurochemistry, 1 , Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein. Catalayud, M. Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue.

International Journal of Molecular Sciences, 14 6 , Garcia-Esparcia, P. Prion, 7 5 , During embryo development, the potency of the zygote is deployed through coordinated and stereotypical changes in cell behaviors and processes of tissue patterning, ultimately resulting in the formation of an entire, highly complex organism in a relatively short period of time. Throughout this process, the developmental potency of individual cells, i.

Our laboratory is interested in understanding the mechanisms that govern the degree of potency of human somatic cells, and how it can be experimentally increased for conditions where doing so may be of biomedical relevance. Heart-related diseases are the main cause of mortality in the world, with ischemic heart disease being the single most frequent condition accounting for the death toll. We pursue the first approach by studying the process of heart regeneration in the zebrafish, an organism with a remarkable capacity for regeneration.

Natural regeneration is a biologically fascinating phenomenon in which somatic cells may regain developmental potency, and we hope that understanding the molecular and cellular mechanisms that control this process will help devising strategies to potentiate the regeneration of adult mammalian hearts. For achieving heart repair, in turn, our research is aimed at generating functional human heart muscle cells that could be used for transplantation. For this purpose, we investigate ways to manipulate the developmental potency of human somatic cells so they become pluripotent i.

Overall, our research takes advantage of a variety of experimental paradigms zebrafish heart regeneration, human iPSC generation and differentiation , approached from a multi-disciplinary perspective, ranging from bioengineering approaches to 3D stem cell differentiation to single-cell genetic lineage tracing analyses and genetic manipulation of human cells, aimed at tackling important current issues in biology and biomedicine, such as the mechanisms that control the establishment and maintenance of developmental potency, the initiation and progression of the regenerative process, and the differentiation and functional maturation of human cardiomyocytes, and the development of genuinely human models of human disease.

Tasset, I. Interplay of LRRK2 with chaperone-mediated autophagy. Nature Neuroscience, 16 4 , Infectious diseases constitute a tenacious and major public health problem all over the world. The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics demand the discovery of new therapeutic approaches.

In addition, there is an urgent need for reliable and rapid detection of infecting bacteria and its pattern of resistance to antibiotics. Bacterial DNA synthesis open new horizons in the discovery of new antibacterial targets due to remarkably differences to the eukaryotic system. The enzyme ribonucleotide reductase RNR catalyzes the reduction of ribonucleotides to the corresponding deoxyribonucleotides dNTP and thereby provides the building blocks for DNA synthesis and repair.

The balance of the different dNTPs has to be carefully regulated and the RNR enzymes as well as its expression play important roles. In the bacterial world it is not known which transcriptional regulators are required to control the expression of the different RNR genes and their role in pathogenesis. Our lab aims to investigate new antimicrobial therapies to combat bacterial infections with different objectives: n First,.

We believe this project will be beneficial to society since we explore the use of different bioengineering approaches to elucidate ways to diagnose and eradicate multi-drug resistant bacteria. The research of our groups is focused on biomechanics, that is, the study of the mechanisms and physiological implications underlying mechanical force in biology.

This research is organized into two different research lines. The respiratory biomechanics line, led by Prof. Daniel Navajas, studies the mechanical behaviour of the respiratory system, and how it is altered in respiratory diseases. The biophysical mechanobiology line, led by Prof. Pere Roca-Cusachs, studies the basic physical and molecular mechanisms by which cells detect and respond to forces. Respiratory biomechanics Daniel Navajas Our goal is to gain a better understanding of cellular and respiratory biomechanics in order to improve the diagnosis and treatment of respiratory disease.

Our work is organized into two interrelated areas, focusing on respiratory mechanics at both the systemic and the cellular level. We use basic and translational approaches in a multidisciplinary framework involving cooperation with clinical research groups working in the field of respiratory medicine. At the systemic level, we study the mechanical properties of the airway and lung tissues and the changes that occur in the context of the mechanical dysfunction associated with respiratory diseases. We study the mechanics of the upper airway in sleep apnea syndrome and on mechanical ventilation in acute and chronic respiratory failure.

We biofabricate engineered lungs by recellularizing lung scaffolds with stem cells. At the cellular level, we develop and apply cutting-edge nanotechnology and advanced biophysical techniques to probe the mechanical behaviour of cells and their mechanical interactions with their microenvironment. We study the mechanical properties of the cell and its response to inflammation and mechanical stresses and develop new approaches to differentiate stem cells using mechanical stimuli. Biophysical mechanobiology Pere Roca-Cusachs, Junior Group Leader Every time we blink, move a hand, draw a breath, or walk, cells in our body exert, transmit, withstand, and detect forces.

This mechanical interaction with the environment determines how cells proliferate, differentiate, and move, and regulates development, tumorigenesis or wound healing. Just like biochemical stimuli initiate signaling cascades, mechanical forces affect the links and conformation of a network of molecules connecting cells to the extracellular matrix.

Our research aims to unravel the mechanisms that these molecules use to detect and respond. Nanomechanics of lung extracellular matrix probed with atomic force microscopy Luque et al. Left: decellularized lung scaffold. Right: mechanical properties probed with AFM. To this end, we combine biophysical techniques like magnetic tweezers, Atomic Force Microscopy, traction microscopy, and microfabricated force sensors with molecular biology and advanced optical microscopy.

Using this approach, we have for instance revealed the different mechanical roles of several adhesion molecules: whereas some are responsible for withstanding forces, others detect and transmit those forces Roca-Cusachs et al. We have also recently unveiled a basic micron-sized molecular structure that cells use to generate forces that probe substrate rigidity Ghassemi et al. Ultimately, when we determine the molecular mechanisms that communicate cells with their environment, we will understand how forces determine development when things go right, and tumor formation when they go wrong.

Mouse embryonic fibroblast before and after mechanical compression. The actin cytoskeleton is shown in red, the membrane in green. Trepat, X. Mechanical guidance of cell migration: lessons from chemotaxis. Current Opinion in Cell Biology, 25 5 , Puklin-Faucher, E. Mechanical signaling driving stem cell differentiation in the lung.

Lung-on-achip model. PI: A. Chair: E. Identifying molecular mechanical pathways in cells Mechanical pathways in cells: from molecular mechanisms to cell function Stromal stiffness in tumor progression Pedotti Bioengineering Dept. Nils Gauthier Mechanobiology Institute, Singapore. Montserrat, J. Is there an optimal nasal pressure for treating obstructive sleep apnea-and if so, what is it? Sleep, 36 4 , Cortiella, J. Local micromechanical properties of decellularized lung scaffolds measured with atomic force microscopy. Acta Biomaterialia, 9 6 , Navajas, D.

Development of a threedimensional bone-like construct in a soft self-assembling peptide matrix. Tissue Engineering Part A, 19 , Lopez-Bernal, E. Cost-effectiveness of a new internet-based monitoring tool for neonatal post-discharge home care. Journal of Medical Internet Research, 15 2 , e Blanch, L.

Barrierprotective effects of activated protein C in human alveolar epithelial cells. Chronic intermittent hypoxia preserves bone density in a mouse model of sleep apnea. Respiratory Physiology and Neurobiology, 3 , Antioxidant effect of human adult adipose-derived stromal stem cells in alveolar epithelial cells undergoing stretch. Respiratory Physiology and Neurobiology, 1 , Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea.

These tools include instrumentation based on proximity probes, such as electrochemical tunnelling microscopy and spectroscopy, that we apply to investigate electron transfer in metal oxides and individual redox proteins. These studies are relevant to the development of biosensors and molecular electronics devices. In particular, we have recently published a method to measure directly the distance decay constant that characterizes the rate of electron transfer ET in redox proteins, and we have reported single protein junctions consisting of azurin bridged between a gold substrate and the probe of an electrochemical tunneling microscope, which constitute a proof-ofprinciple of a single redox protein field-effect transistor.

Another set of nanotools that we are developing is based on molecular actuators that can be switched with light, such as azobenzene, which can be chemically attached to biomolecules in order to optically control their activity. We are specifically interested in the processes of neurotransmitter secretion by exocytosis and membrane recycling by endocytosis, which are the fundamental phenomena that occur at the synaptic terminal and that participate in the communication between neurons. We have recently set up a method to control neurotransmitter exocytosis with light at the presynaptic compartment by activating a calcium-permeable, light-gated glutamate receptor LiGluR in cultured cells.

Presynaptic expression of LiGluR in hippocampal neurons enables direct and reversible control of neurotransmission with light, and has allowed for the first time the modulation of the firing rate of the postsynaptic neuron with the wavelength of illumination.

Lightregulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis. Angewandte Chemie, 52 30 , Nakamura, H. Controlling formation of single-molecule junctions by electrochemical reduction of diazonium terminal groups. JACS, 9 , Giannotti, M. Enhanced cell-material interactions through the biofunctionalization of polymeric surfaces with engineered peptides. Biomacromolecules, 14 8 , Bioactive nanomembranes of semiconductor polythiophene and thermoplastic polyurethane: thermal, nanostructural and nanomechanical properties.

Polymer Chemistry, 4 3 , Ernest Giralt Dept. Mireia Oliva Dept. Artur Llobet Dept. Dirk Trauner Chemistry Dept. Morphological and nanomechanical behavior of supported lipid bilayers on addition of cationic surfactants. Langmuir, 29 30 , Optical control of calcium-regulated exocytosis.

Biochimica et Biophysica Acta, 3 , Briones, F. Tin passivation in alkaline media: Formation of SnO microcrystals as hydroxyl etching product. Electrochimica Acta, , Study and improvement of aluminium doped ZnO thin films: Limits and advantages. Incorporation of Ubiquinone in supported lipid bilayers on ITO. Journal of Physical Chemistry B, 25 , Beilstein Journal of Organic Chemistry, 9, Tensile response and fracture and failure behavior of jute fabrics-flyash-vinylester hybrid composites.

Fibers and Polymers, 14 2 , Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR. Frontiers in Molecular Neuroscience, 6 Article 3 , AFMbased force-clamp indentation: Force-clamp monitors the lipid bilayer failure kinetics. Crystal structure of redox protein azurin Protein Data Bank entry: 1AZU displaying its solvent accessible surface gold superimposed on the tertiary structure rainbow and a red sphere indicating the copper ion.

Electrochemically-gated singlemolecule electrical devices. The ability of eukaryotic cells to migrate within living organisms underlies a wide range of phenomena in health and disease. When properly regulated, cell migration enables morphogenesis, host defense and tissue healing. When regulation fails, however, cell migration mediates devastating pathologies such as cancer, vascular disease and chronic inflammation.

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Our research focuses on understanding the fundamental biophysical mechanisms underlying migration both at the single cell level and at the tissue level. Making cellular forces visible To study cell and tissue dynamics we develop new technologies to measure cellular velocities and physical forces at the cell-cell and cell-matrix interface. Using these techniques we unveiled a new mechanism of cellular guidance by intercellular physical forces we called plithotaxis. Our new tools also led to the discovery of an unanticipated mechanical wave that propagates through expanding cell sheets.

This mechanical wave is a natural candidate to trigger mechanotransduction pathways during wound healing, morphogenesis, and collective cell invasion in cancer.

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